When should I apply it?

Apply 60–90 minutes before your procedure. Clean and dry the skin first, layer it on thick, then cover with plastic wrap. The wrap is what drives absorption — don't skip it.

Where on the body can I use it?

TAT2NUMB is safe on most external skin surfaces. Avoid mucous membranes and the area around the eyes. If you're unsure about a specific placement, check with your artist or a medical professional.

Why not just use a drugstore cream?

Most OTC creams rely on lidocaine alone at lower concentrations. TAT2NUMB uses a multi-agent formula — the combination works faster, penetrates deeper, and holds through longer sessions than single-agent alternatives.

I have sensitive skin. Is this right for me?

The formula is designed for healthy, intact skin. If you have a known sensitivity to local anesthetics, or take medications that interact with lidocaine, consult your doctor before use. Discontinue immediately if irritation occurs.

What are the full ingredients?

Active Ingredients: Lidocaine Base, Prilocaine Base, Epinephrine. Inactive Ingredients: Glycerin, Isopropyl Alcohol, Cream Base, Distilled Water. Store below 86°F. Keep out of reach of children. For external use only.

Lidocaine + Prilocaine: Why Multi-Agent Numbing Formulas Work Better

Name: TAT2NUMB Professional Numbing Cream
Brand: TAT2NUMB
SKU: TAT2NUMB-001
Price: 24.99 USD
Availability: InStock

Combining lidocaine and prilocaine in a single topical formula produces stronger and longer-lasting numbing than either drug achieves on its own. The mechanism is documented in clinical pharmacology and forms the basis of EMLA cream, one of the most studied topical anesthetic preparations in medicine. TAT2NUMB uses this same dual-agent approach, adding epinephrine as a vasoconstrictor for extended duration and reduced surface bleeding.

How Local Anesthetics Block Pain Signals

Local anesthetics work by blocking voltage-gated sodium channels in nerve cell membranes. When sodium ions cannot enter the cell, the nerve cannot fire an action potential, and no pain signal reaches the brain. Every agent in this class shares that core mechanism. The meaningful differences between agents come down to lipid solubility, protein binding affinity, and metabolic half-life.

What Lidocaine Does at 4%

Lidocaine is the most widely used local anesthetic in clinical medicine. At 4% concentration in a topical formulation, it begins numbing superficial tissue within 20 to 30 minutes, aided by high lipid solubility that supports fast stratum corneum penetration. Without pharmacological support, the block can begin tapering at 60 to 90 minutes as the drug diffuses into systemic circulation.

What Prilocaine Adds to the Formula

Prilocaine is also an amide anesthetic, structurally similar to lidocaine but with meaningfully different tissue behavior. It has a slightly slower onset and broader tissue distribution, and it is metabolized more slowly. In a combined formula, it maintains the block as lidocaine begins to taper, extending the numbing window without requiring a larger dose of either drug.

Prilocaine also carries a lower potential for cardiovascular toxicity at equivalent doses. Using both agents at moderate concentrations keeps individual drug loads lower while the combined effect remains strong.

The Clinical Case for Dual-Agent Formulas

The lidocaine-prilocaine combination is synergistic, not merely additive. The original EMLA clinical studies showed that the eutectic mixture produced greater dermal anesthesia depth than either compound used alone at matched concentrations. Each agent enhances the penetration of the other through changes in the mixture's melting point and lipid solubility behavior.

The Role of Epinephrine

Epinephrine is a vasoconstrictor, not an anesthetic. In this formula, it constricts blood vessels in the treated area, slowing the rate at which the anesthetic agents absorb into systemic circulation. Slower absorption means the drugs remain localized longer and the effective duration extends further. A secondary benefit is reduced surface bleeding at the needle site.

Do not rub TAT2NUMB into the skin. Apply a thick, occlusive layer and cover immediately with plastic wrap. Rubbing thins the product and reduces contact time with the stratum corneum, which directly shortens numbing duration. Thick application under occlusion is the correct technique.

Application Timing and Technique

Apply the cream 60 to 90 minutes before the procedure begins. Earlier application does not improve results and increases systemic absorption time.
Use the full packet for thorough, even coverage of the target area. Sparse application reduces both depth and duration.
Apply in a thick layer. Do not spread thin or rub into the skin.
Cover immediately with plastic wrap to maintain occlusion and retain body heat, which aids penetration through the stratum corneum.
Remove the wrap and wipe the area clean immediately before the artist begins.
Do not extend the application window significantly beyond 90 minutes. Prolonged occlusion does not meaningfully improve results and increases the risk of systemic absorption.

Professional Use and Availability

Multi-agent formulas are standard in clinical dermatology and cosmetic procedures for a reason. They outperform single-agent products across the procedure lengths that matter most. TAT2NUMB is available for individual purchase and professional wholesale, with retail packs starting at $24.99 and bulk pricing at 3, 5, and 10-pack tiers. Orders placed before 12pm Monday through Friday ship the same day.